Concomitant use of dihydrocodeine and sedative medicines including benzodiazepines or relevant drugs may cause sedation, respiratory depression, coma and death. On account of these risks, concomitant prescribing with these sedative medicines should be reserved for patients for whom alternative treatment solutions are impossible. If a decision is made to prescribe dihydrocodeine concomitantly with sedative medicines, the bottom helpful dose should be employed, plus the duration of treatment ought to be as brief as possible (see also common dose suggestion in section 4.
Cough medicines containing dihydrocodeine are controlled likewise to dextromethorphan from the United States, in that its sale is strictly constrained by buy quantity and is limited to folks 20 and more mature for order.
This side outcome need to dress in off within a couple of days as One's body gets utilized to dihydrocodeine. Talk with a health care provider if it carries on for longer.
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The chance of acquiring serotonin syndrome may differ between different opioid and serotonergic medicine mixtures
If each medicines are prescribed together, your health care provider may well change the dose or how often you utilize 1 or both on the medicines.
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Two famed customers of dihydrocodeine have been William S. Burroughs, who described it as "twice as strong as codeine and Practically as good as heroin" and Hermann Göring, who was a known morphine addict (Hitler referred to him as being the "morphinist"), consumed around one hundred tablets (3 grams) of dihydrocodeine daily and was captured with the Allies with a large amount on the drug in the suitcase, reportedly additional than twenty,000 tablets[citation essential].
The serotonergic potential of opioids is increasingly recognised. When prescribing opioids with serotonergic medicines, consider the opportunity of a drug-drug interaction resulting in serotonin syndrome.3
Sử dụng thuốc kéo dài có thể dẫn đến lệ thuộc thuốc (gây nghiện), đặc biệt ở những người có tiền sử lạm dụng chất gây nghiện hoặc rối loạn tâm thần như trầm cảm nặng.
Agitation anxiousness bleeding gums bloating bloody or black, tarry stools bloody or cloudy urine blue lips and fingernails blurred vision upper body pain or discomfort chills cold sweats confusion constipation continuing ringing or buzzing or other unexplained sound during the ears awesome, pale skin coughing that sometimes creates a pink frothy sputum dark urine darkening on the skin depression diarrhea difficult, quick, noisy breathing dizziness, faintness, or lightheadedness when acquiring up out of the blue from the lying or sitting down situation drowsiness dry mouth rapid, pounding, or irregular heartbeat or pulse rapid, slow, or irregular heartbeat fever flushed, dry pores and skin fruit-like breath odor normal tiredness and weak point considerably decreased frequency of urination or amount of urine headache headache, unexpected and critical hearing loss heartburn enhanced hunger increased sensitivity to pain amplified sweating enhanced thirst greater urination indigestion massive, hive-like swelling around the face, eyelids, lips, tongue, throat, palms, legs, ft, or genitals light-colored stools loss of appetite loss of consciousness muscle mass cramps, spasms, pain, weakness, or stiffness muscle mass tremors nausea nervousness nightmares numbness and tingling with the encounter, lips, arms, and feet overactive reflexes pains within the stomach, side, or abdomen, possibly radiating to the back pinpoint red spots over the skin very poor coordination speedy, deep respiratory restlessness seizures serious stomach pain shakiness shivering skin get more info rash slurred speech stomach pain, cramping, or burning sunken eyes swelling from the legs, ft, or ankles trembling or shaking issues with respiratory twitching unexplained weight loss uncommon bleeding or bruising abnormal drowsiness, dullness, tiredness, weakness, or feeling of sluggishness upper ideal abdominal or stomach pain vomiting vomiting of blood or substance that appears like coffee grounds vomiting, critical or steady weak point or heaviness of the legs worsening of pain wrinkled skin yellow eyes or pores and skin Get crisis help quickly if any of the next symptoms of overdose come about:
This product could contain inactive ingredients, which could cause allergic reactions or other difficulties. Speak with your pharmacist For additional details.
Stick to basic foods - prevent wealthy or spicy foods. Take your doses after food, as this will likely help protect your stomach
This medicine is surely an opioid painkiller. There is a significant threat of addiction when having this medicine, particularly if employed long-term. The Medicines and Healthcare products Regulatory Agency (MHRA) has issued new guidance for men and women prescribed an opioid painkiller.